Quantitative assessment of peripheral metabolism and perfusion with dynamic 1H MRI in healthy and diabetic individuals
Ryan Wahidi1, Yi Zhang2, Ran Li1, Mohammed A. Zayed3, Mary K. Hastings4, and Jie Zheng1
1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2Zhejiang University, Hangzhou, China, 3Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, United States, 4The Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, United States
The objective of this study is to analyze the efficacy of quantitative PCr MRI in quantifying differing muscle tissue PCr kinetics in healthy individuals and diabetic patients. Healthy subjects and diabetic patients underwent PCr and perfusion imaging in calf muscle at rest, during isometric plantarflexion, and for a recovery period. Only the healthy group displayed moderate correlation between PCr and perfusion. The diabetic patient group displayed attenuated recovery speed of PCr after exercise and no correlation between PCr and perfusion.
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