Abstract #3418

Pre-Therapy Ferumoxytol-Enhanced Magnetic Resonance Imaging (MRI) Predicts Response of Metastatic Breast Cancer to Liposomal Irinotecan

Harshan Ravi¹, Andres M. Arias Lorza¹, James R. Costello², Hyo Sook Han³, Daniel K. Jeong², Stephan G. Klinz Klinz⁴, Jasgit C. Sachdev⁵, Ronald L. Korn⁶, and Natarajan Raghunand^1,7

¹Department of Cancer Physiology, Moffitt Cancer Center and Research Institute, Tampa,, FL, United States, ²Department of Radiology, Moffitt Cancer Center and Research Institute, Tampa,, FL, United States, ³Department of Breast Oncology, Moffitt Cancer Center and Research Institute, Tampa,, FL, United States, ⁴Ipsen Bioscience, Cambridge, MA, United States, ⁵HonorHealth Research Institute, Scottsdale, AZ, United States, ⁶Imaging Endpoints Core Lab, Scottsdale, AZ, United States, ⁷Department of Oncologic Sciences, University of South Florida, Tampa,, FL, United States

Synopsis

R^*₂ and the apparent concentration of FMX in the tumor (FMX_C) are considered biomarkers of liposomal irinotecan (nal-IRI) drug uptake into that tumor lesion, which in turn would determine response of that tumor to nal-IRI. Historically, quantification of R^*₂ and FMX_C had been implemented by using a calibration phantom and acquiring patient scans both pre-FMX and post-FMX. Here we have demonstrated a pre-treatment FMX-enhanced MRI companion biomarker of response to nal-IRI in mBC patients that can be computed from a single16-24 h post-FMX MRI scan without the need for calibration phantoms or pre-FMX scans.

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