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Abstract #3421

Feasibility and repeatability of oxygen-enhanced T1 measurements in primary colorectal cancer: a prospective study in 22 patients.

Davide Prezzi1, Radhouene Neji1,2, Isabel Dregely1, Sami Jeljeli1, Paul Bassett3, Gary Cook1, and Vicky Goh1
1King's College London, London, United Kingdom, 2Siemens Healthineers, Frimley, United Kingdom, 3Statsconsultancy Ltd, Amersham, United Kingdom


Oxygen-enhanced ΔT1 tumor measurements were feasible in 12/22 colorectal cancer patients by means of single-slice MOLLI. A small but statistically significant negative tumor ΔT1 was found overall, in line with the expected response in well perfused and oxygenated tissue [mean (95% CI) ΔT1 = -33 (-41, -25) msec; mean tumor T1 = 1545 ± 163 msec]. A significant negative MOLLI ΔT1 was found in muscle. Repeatability and interobserver agreement were acceptable. Multi-slice variable-flip-angle VIBE tumor T1 measurements were degraded by motion or susceptibility artefact. Technical developments aimed at mitigating artefact and amplifying ΔT1 are needed for future clinical translation.

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