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Abstract #3430

DWI Metrics Differentiating Intraductal Papillary Mucinous Neoplasms from Pancreatic Cancer: A study in GEM Models

Miguel Romanello Giroud Joaquim1, Emma E Furth2, Yong Fan2, Hee Kwon Song2, Stephen Pickup2, Jianbo Cao3, Hoon Choi2, Mamta Gupta2, Cynthia Clendenin2, Thomas Karasic2, Jeffrey Duda2, James Gee2, Peter O'Dwyer2, Mark Rosen2, and Rong Zhou1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2University of Pennsylvania, Philadelphia, PA, United States, 3University of Cambridge, Cambridge, United Kingdom


Intraductal Papillary Mucinous Neoplasms (IPMN) are recognized as important precursors to invasive pancreatic ductal adenocarcinoma (PDAC). While IPMN requires surveillance without treatment, a clinical marker is lacking which can identify those undergoing malignant transformation. In two genetic engineered mouse models (KPC and CKS), which resemble human PDAC and IPMN, respectively, we tested the hypothesis that differences in cellular architecture and stromal features between PDAC and IPMN present themselves in DW-MRI and /or DCE-MRI metrics. Our data revealed an almost complete separation of ADC values between CKS (benign) vs. KPC (malignant) tumors and identified histopathological features corroborating the imaging metrics.

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