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Abstract #3446

3D-CAIPI-BUDA and Joint Hankel Low-Rank Reconstruction Enable Rapid and Distortion-free High-Resolution T2* Mapping and QSM

Zhifeng Chen1,2,3, Congyu Liao4, Xiaozhi Cao4, Benedikt A Poser5, Zhongbiao Xu6, Wei‐Ching Lo7, Manyi Wen8, Jaejin Cho1, Qiyuan Tian1, Yaohui Wang9, Yanqiu Feng3, Wufan Chen3, Ling Xia10, Feng Liu11, and Berkin Bilgic1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Charlestown, MA, United States, 3School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, 4Department of Radiology, Stanford University, Stanford, CA, United States, 5Maastricht Brain Imaging Center, Faculty of Psychology and Neuroscience, University of Maastricht, Maastricht, Netherlands, 6Department of Radiotherapy, Cancer Center, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Science, Guangzhou, China, 7Siemens Medical Solutions, Boston, MA, United States, 8Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China, 9Division of Superconducting Magnet Science and Technology, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China, 10Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 11School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia


Quantitative imaging has been very useful in neuroscientific and clinical applications, including glioma, tumor diagnosis and prognosis, brain maturation, and Alzheimer's disease. EPI is a powerful tool for quantitative imaging owing to its extremely fast acquisition. This work aims to develop a distortion-free, blip-up/down acquisition (BUDA) 3D-EPI with controlled aliasing in parallel imaging (CAIPI) sampling and joint Hankel low-rank image reconstruction for fast and robust multi-contrast high-resolution whole-brain imaging. The developed technique could generate distortion-free high-resolution whole-brain T2* mapping and quantitative susceptibility mapping in 47s at 1.1×1.1×1 mm3 resolution.

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