Abstract #3496

Towards Whole Brain Diffusion Tensor Spectroscopic Imaging

Bruno Sa de la Rocque Guimaraes^1,2, Khaled Talaat^1,2, Michael Mullen³, Essa Yacoub³, and Stefan Posse^1,4

¹Neurology Department, University of New Mexico, Albuquerque, NM, United States, ²Nuclear Engineering Department, University of New Mexico, Albuquerque, NM, United States, ³Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ⁴Physics and Astronomy Department, University of New Mexico, Albuquerque, NM, United States

Synopsis

Here we describe the development of a high-spatial resolution multi-slice single-shot Diffusion-Tensor proton-echo-planar-spectroscopic-imaging (PEPSI) technique using a binomial spatial-spectral refocusing RF pulse for mapping the diffusion tensor of water, Cho, Cr and NAA. Analysis of NAA and water diffusion in white matter obtained in a 4-slice acquisition with 1cc voxel size in 6 minutes (b_max = 2430.7 mm²/s) showed a mean ADC value of 0.15*10^-3 and 0.66*10^-3 mm²/s, which is consistent with values reported in the literature. Single-shot high spatial resolution diffusion sensitive MR spectroscopic imaging has the potential to probe metabolite diffusion across extended brain regions.

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