Hyperpolarized 129Xe MRI provides a way to investigate and assess pulmonary diseases. To improve the performance of 129Xe MRI in lung imaging, a method for acquiring two VDP calculations using high-resolution 3D static ventilation imaging from FGRE combined with a key-hole method was proposed and demonstrated in participants with ventilation abnormalities. SNR was calculated as well as semi-automated VDP and fully automated VDP, which showed a strong positive linear correlation with a zero intercept and close to unity slop. This study confirms the feasibility of using isotropic-voxel 129Xe MRI acquired in a single breath-hold to study ventilation heterogeneity.
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