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Abstract #3534

Skeletal Muscle Metabolism in Obesity Measured by Hyperpolarized [1-13C]pyruvate

Jun Chen1, Junjie Ma1, James Ratnakar1, Shawn C Burgess2,3, Craig R Malloy1,4,5, and Jae Mo Park1,4,6
1AIRC, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, 2Center for Human Nutrition, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, 3Pharmacology, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, 4Radiology, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, 5Internal Medicine, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, 6Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States

Synopsis

Obesity is associated with insulin resistance and chronic inflammation, both of which are known to affect skeletal muscle metabolism. However, studies in the impact of obesity on metabolism mainly focus on adipose tissue, instead of skeletal muscle. This study analyzes the in vivo pyruvate metabolism in the skeletal muscle of obese volunteers with hyperpolarized [1-13C]pyruvate. The results indicate increased lactate production and decreased pyruvate dehydrogenase activity in the skeletal muscle of obesity.

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