We optimize the sampling length parameter of Radial Diffusion Spectrum Imaging (RDSI) to improve fiber reconstruction accuracy of ODF-Fingerprinting (ODF-FP). As the ground truth, we use anisotropic diffusion phantoms containing taxons (textile water-filled tubes) with inside diameter of 0.8µm, approaching the anatomical scale of axons found in the human brain. Thanks to our optimized approach, ODF-FP reconstructs fibers crossing at angles as narrow as 10, 15, and 20 degrees with the average accuracy of approximately 10 degrees. We generalize our observations by proposing a criterion for selecting near-optimal sampling lengths to accelerate and simplify the application of ODF-FP with RDSI.
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