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Abstract #3568

Quantifying Ventilation Using Dynamic Xenon MRI During Free Breathing

Hooman Hamedani1, Faraz Amzajerdian1, Stephen Kadlecek1, Ryan Baron1, Kai Ruppert1, Ian Duncan1, Mostafa Ismail1, Yi Xin1, Tahmina Achekzai1, Luis Loza1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States


In order to image function in the free breathing lung with high temporal and special resolution, we have developed a passive, mechanically controlled MR-friendly gas delivery device capable of real time dosimetry and end-tidal gas measurements that can be used in combination with a non-rigid image registration technique. These dynamic images can thus be translated into comprehensible quantitative maps of lung ventilation and gas exchange. In order to image the lung continuously during normal breathing, we have also developed a fast-acquisition pulse sequence that uses diaphragm position to facilitate image reconstruction.

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