Meeting Banner
Abstract #3629

Neuroimaging-based brain age prediction of first-episode schizophrenia and the alteration of brain age after early medication

Xu-Sha Wu1, Yi-Bin Xi1, and Hong Yin1
1Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China


Schizophrenia is related to accelerated brain ageing, while individualized biomarkers are scarce. We established a brain age prediction model based on diffusion tensor imaging sequence. The difference between brain age and chronological age of first-episode schizophrenia patients and healthy controls were compared, and the longitudinal studies were performed in follow-up patients after a short-term antipsychotic treatment. The results verified the theory of accelerated brain ageing and medication have an effect on ameliorating it. Structural brain changes in schizophrenia could reveal the accelerated aging and quantification of age discrepancy could contribute to clinical decision-making and find new targeted therapies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here