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Abstract #3653

Free-breathing Water-fat Separation and T1 Mapping of the Whole Liver with Isotropic Resolution using 3D Golden Angle Radial Trajectory

Yajie Wang1, Haikun Qi2, Yishi Wang3, and Huijun Chen1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 3Philips Healthcare, Beijing, China


T1 mapping of the liver has been used for the diagnosis and grading of the liver disease, and the evaluation of the liver function, while conventional liver T1 mapping techniques need breath-holding, have limited slice coverage or need multiple acquisitions. In addition, the accuracy of the T1 quantification is affected by the presence of fat in the liver. In this study, free-breathing water-fat separation and T1 mapping quantification of the whole liver was achieved within one scan using the proposed mGOAL-SNAP sequence. The quantitative accuracy and the in-vivo feasibility of mGOAL-SNAP have been demonstrated in phantom and volunteers studies.

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