Abstract #3656

Quantitative CAIPIRINHA-Dixon-TWIST-VIBE parameters correlate with molecular subtypes of invasive ductal carcinoma

Tianwen Xie¹, Tingting Jiang¹, Caixia Fu², Marcel Dominik Nickel³, Weijun Peng¹, and Yajia Gu¹

¹Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, ²MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ³MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

In this study, we analyzed the relationship between CAIPIRINHA-Dixon-TWIST-VIBE (CDTV)-derived DCE parameters and clinicopathological factors, including molecular subtypes of invasive ductal carcinoma (IDC). Our results showed that the values of semi-quantitative parameters were similar for various prognostic factors and molecular subtypes of IDC. However, the values of quantitative inline pharmacokinetic kinetic parameters, k_ep_minimum and k_ep_difference, were significantly different for the luminal A and HER2-positive subtypes. AUC value for accurately distinguishing luminal A and HER2-positive subtypes based on combined k_ep_minimum and k_ep_difference values was 0.820. Therefore, our study demonstrates that CDTV-derived quantitative parameters are associated with molecular subtypes of IDC.

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