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Abstract #3656

Quantitative CAIPIRINHA-Dixon-TWIST-VIBE parameters correlate with molecular subtypes of invasive ductal carcinoma

Tianwen Xie1, Tingting Jiang1, Caixia Fu2, Marcel Dominik Nickel3, Weijun Peng1, and Yajia Gu1
1Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, 2MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 3MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany


In this study, we analyzed the relationship between CAIPIRINHA-Dixon-TWIST-VIBE (CDTV)-derived DCE parameters and clinicopathological factors, including molecular subtypes of invasive ductal carcinoma (IDC). Our results showed that the values of semi-quantitative parameters were similar for various prognostic factors and molecular subtypes of IDC. However, the values of quantitative inline pharmacokinetic kinetic parameters, kep_minimum and kep_difference, were significantly different for the luminal A and HER2-positive subtypes. AUC value for accurately distinguishing luminal A and HER2-positive subtypes based on combined kep_minimum and kep_difference values was 0.820. Therefore, our study demonstrates that CDTV-derived quantitative parameters are associated with molecular subtypes of IDC.

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