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Abstract #3674

The value of APTw imaging combined with ALP to identify Prostate Cancerwith or withoutBone Metastasis

Chen Lihua1, Song Qingwei1, Gao Mingli1, Wang Jiazheng2, Lin Liangjie2, Wu Zhigang2, and Liu Ailian1
1The First Affiliated Hospital of Dalian Medical University, DaLian, China, 2Philips Healthcare, Beijing, China


Amide proton transfer-weighted (APTw) imaging is a novel MRI imaging tool for detection of amide protons in mobile cellular proteins and peptides. This study aims to assess and differentiate prostate cancers with and without bone metastasis using APTw MRI and alkaline phosphatase (ALP).Results show that prostate cancers with bone metastasis were associated with significantly higher APTw and ALP values than those without bone metastasis. The diagnostic efficiency is the highest using APT combined with ALP. Therefore, APTw imaging together with ALP may provide an more effective tool to predict the aggressiveness of prostate cancer.

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