Amide proton transfer-weighted (APTw) imaging is a novel MRI imaging tool for detection of amide protons in mobile cellular proteins and peptides. This study aims to assess and differentiate prostate cancers with and without bone metastasis using APTw MRI and alkaline phosphatase (ALP).Results show that prostate cancers with bone metastasis were associated with significantly higher APTw and ALP values than those without bone metastasis. The diagnostic efficiency is the highest using APT combined with ALP. Therefore, APTw imaging together with ALP may provide an more effective tool to predict the aggressiveness of prostate cancer.
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