The oscillating frequency and SNR are important for accurate microstructural mapping in diffusion-time-dependent diffusion MRI, which however, are limited on clinical scanners. This study demonstrated that the dMRI acquisition protocol with frequency up to 50 Hz achieved significant higher accuracy than that with 33Hz, based on 1) Monte-carlo simulation, 2) clinical data on 37 breast tumor patients, and 3) correlation with histological data. Also, for the first time, we demonstrated the feasibility of oscillating gradient dMRI-based microstructural mapping in distinguishing breast tumor status clinically.
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