Effects of oscillating frequency and SNR on quantifying microstructural properties in breast tumor using oscillating gradient diffusion MRI
Ruicheng Ba1, Xiaoxia Wang2, Zelin Zhang1, Hsu Yi-Cheng3, Yi Sun3, Jiuquan Zhang2, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China, 3MR Collaboration, Siemens Healthineers Ltd., Shanghai, China
The oscillating frequency and SNR are important for accurate microstructural mapping in diffusion-time-dependent diffusion MRI, which however, are limited on clinical scanners. This study demonstrated that the dMRI acquisition protocol with frequency up to 50 Hz achieved significant higher accuracy than that with 33Hz, based on 1) Monte-carlo simulation, 2) clinical data on 37 breast tumor patients, and 3) correlation with histological data. Also, for the first time, we demonstrated the feasibility of oscillating gradient dMRI-based microstructural mapping in distinguishing breast tumor status clinically.
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