Neuroblastoma (NB) is most often diagnosed in young children, and high-risk NB indicates a poor prognosis and requires aggressive treatment. Here, we assessed the utility of radiomics for amide proton transfer (APT) imaging in the preoperative classification of high-risk and low-risk abdominal NBs. Thirty-three pediatric patients underwent APT scans, with 16 confirmed high-risk NBs and 17 confirmed low-risk NBs. Radiomic models were constructed from four APT-related metric maps using 7 classifiers, with their prediction performances evaluated by associated AUCs. The optimal model achieved an AUC of 0.86, demonstrating the potential of APT MRI-based radiomics for risk stratification of NB.
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