Abstract #3726

Reconstructing a four-dimensional diffusion magnetic resonance imaging atlas of the fetal brain

Ruike Chen¹, Cong Sun², Yuhao Liao¹, Tingting Liu¹, Junyan Wang³, Yi-Cheng Hsu⁴, Yi Sun⁴, Yi Zhang¹, Guangbin Wang², and Dan Wu¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China, ³Zhejiang Lab, Hangzhou, China, ⁴MR Collaboration, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Diffusion MRI (dMRI) is a powerful tool to characterize the developing brain, e.g., to map the spatiotemporal development of early white matter (WM) in the fetal brain and to quantify microstructural changes for diagnosis of prenatal disorders. We proposed a pipeline for dMRI atlas generation with fiber orientation distribution-based registration and shape update, and constructed the first spatiotemporal dMRI atlas of the fetal brain in a Chinese population of 90 normal fetuses from 24 to 38 gestational weeks. The atlas provided information for deciphering the morphological and microstructural development of WM tracts during the second to third trimester.

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