Reconstructing a four-dimensional diffusion magnetic resonance imaging atlas of the fetal brain
Ruike Chen1, Cong Sun2, Yuhao Liao1, Tingting Liu1, Junyan Wang3, Yi-Cheng Hsu4, Yi Sun4, Yi Zhang1, Guangbin Wang2, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China, 3Zhejiang Lab, Hangzhou, China, 4MR Collaboration, Siemens Healthineers Ltd., Shanghai, China
Diffusion MRI (dMRI) is a powerful tool to characterize the developing brain, e.g., to map the spatiotemporal development of early white matter (WM) in the fetal brain and to quantify microstructural changes for diagnosis of prenatal disorders. We proposed a pipeline for dMRI atlas generation with fiber orientation distribution-based registration and shape update, and constructed the first spatiotemporal dMRI atlas of the fetal brain in a Chinese population of 90 normal fetuses from 24 to 38 gestational weeks. The atlas provided information for deciphering the morphological and microstructural development of WM tracts during the second to third trimester.
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