This study aimed to profile the metabolic differences of colorectal cancer tissues (CCT) in different stages and sites, as compared with their adjacent noncancerous tissues (ANT), to investigate the temporal and spatial heterogeneities of metabolic characterization. Our NMR-based metabonomics fingerprinting revealed that many of the metabolite levels were significantly altered in CCT as compared with ANT, indicating deregulations of glucose metabolism, one-carbon metabolism, glutamine metabolism, amino acid metabolism, fatty acid metabolism, TCA cycle, choline metabolism, ect. Significant metabolic differences were found in CRC tissues at different pathological stages and sites, suggesting temporal and spatial heterogeneities of metabolic characterization in CCT.
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