Abstract #3749

Cerebrovascular dysfunction leads to related Gray Matter loss in HIV infection

Bei Wang¹, He Wang^1,2, Ying-Hua Chu³, Yuxin Shi⁴, Dan-Chao Cai⁴, and Yi Zhan⁴

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Human Phenome Institute, Fudan University, Shanghai, China, ³MR Collaboration, Siemens Healthineers Ltd., Shanghai, China, ⁴Radiology department，Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

Synopsis

We examined the effects of HIV on the structure of cerebrovasculature and the interactions among HIV infection, brain tissue volume and cerebrovascular structure. Decreased cerebral vessel volume, vessel length and branch number were found in people with HIV. HIV related gray matter loss was found caused by the decreasing vessel length. Additionally, decreasing vessel distribution in left insula was found in vessel probability atlas in people with HIV, which may relate to various clinical symptoms.

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