Cerebrovascular dysfunction leads to related Gray Matter loss in HIV infection
Bei Wang1, He Wang1,2, Ying-Hua Chu3, Yuxin Shi4, Dan-Chao Cai4, and Yi Zhan4
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Human Phenome Institute, Fudan University, Shanghai, China, 3MR Collaboration, Siemens Healthineers Ltd., Shanghai, China, 4Radiology department，Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
We examined the effects of HIV on the structure of cerebrovasculature and the interactions among HIV infection, brain tissue volume and cerebrovascular structure. Decreased cerebral vessel volume, vessel length and branch number were found in people with HIV. HIV related gray matter loss was found caused by the decreasing vessel length. Additionally, decreasing vessel distribution in left insula was found in vessel probability atlas in people with HIV, which may relate to various clinical symptoms.
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