Automatic Targeting of the Dorsolateral Subthalamic Nucleus for Functional Connectivity Guided rTMS Therapy
Na Zhao1,2,3,4,5, Yang Qiao 1,2,3,4,6, Juan Yue1,2,3, Ying Jing1,2,3, Meng Zhang1,2,3, Jianguo Zhang7, Zhen Yuan4,6, Yong Zhang8, Yu-Tao Xiang4,5, Jue Wang9, and Yu-Feng Zang1,2,3
1Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China, Hangzhou, China, 2Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China, Hangzhou, China, 3Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China, Hangzhou, China, 4Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China, Taipa, Macau, 5Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China, Taipa, Macau, 6Faculty of Health Sciences, University of Macau, Macao SAR, China, Taipa, Macau, 7Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical, Beijing, China, 8MR Research, GE Healthcare, Shanghai, China, Shanghai, China, 9Institute of sports medicine and health, Chengdu Sport University, Chengdu, China, Chengdu, China
The current study developed an AutoSTN method to help automatically localize the dorsolateral STN (DL-STN) according to steps in deep brain stimulation (DBS). Furthermore, for the consideration of the RS-fMRI FC-guided rTMS clinical study and application, we developed one-stop plug-in named ‘CC-CAT’ which could serve any RS-fMRI FC-guided rTMS treatment.
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