Dissecting Brain-wide Olfactory Dysfunctions in Accelerated Aging Rodent Model
Teng Ma1,2,3, Xunda Wang1,2, Linshan Xie1,2, Pit Shan Chong4, Venice Sin1,2, Peng Cao3, Pek-Lan Khong3, Lee Wei Lim4, Alex T. L. Leong1,2, and Ed. X Wu1,2,4
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 4School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
The olfactory system plays a pivotal role in driving behavioral responses that are critical to survival. In particular, the decline in ability to detect and discriminate odors in aged humans lead to an overall decrease in quality of life. However, our present understanding of olfactory dysfunction in aging brains beyond the cellular and micro-circuit level is scarce and incomplete. In this study, we deployed optogenetic fMRI to reveal the changes of brain-wide odor-associated regions brought about by aging in an accelerated aging rat model. We found diminished activations brain-wide indicating dysfunction at the systems level across multiple long-range olfactory pathways.
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