Noninvasive measurement of axon radii has always been challenging using in vivo diffusion MRI (dMRI) data. Although dMRI allows estimation of the effective radius, a very high gradient strength scanner is required to acquire the data. In our proposed method, we overcome this limitation by using analytical methods to accurately predict the signal at high b-values from reasonably lower b-value data that can be obtained from a Prisma-like scanner. Our findings, both in synthetic data and in vivo dMRI data, show that estimating axon radii reliably is possible using dMRI data with a certain SNR level.
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