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Abstract #3804

Axon radii estimation from dMRI data acquired from a non-fancy MRI scanner

Debdut Mandal1, Lipeng Ning2, and Yogesh Rathi2
1Electronics and Electrical Communication Engineering, Indian Institute of Technology Kharagpur, Kharagpur, India, 2Harvard Medical School, Boston, MA, United States


Noninvasive measurement of axon radii has always been challenging using in vivo diffusion MRI (dMRI) data. Although dMRI allows estimation of the effective radius, a very high gradient strength scanner is required to acquire the data. In our proposed method, we overcome this limitation by using analytical methods to accurately predict the signal at high b-values from reasonably lower b-value data that can be obtained from a Prisma-like scanner. Our findings, both in synthetic data and in vivo dMRI data, show that estimating axon radii reliably is possible using dMRI data with a certain SNR level.

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