Abstract #3808

Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T

Jeryn Chang¹, Frederik Steyn^1,2,3,4, Shyuan Ngo^2,3,4,5, Robert Henderson^2,3,4, Christine Guo⁶, Steffen Bollmann^7,8, Jurgen Fripp⁹, Markus Barth^7,8, and Thomas B Shaw^2,7,8

¹School of Biomedical Sciences, The University of Queensland, St Lucia, Australia, ²Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Australia, ³Wesley Medical Research, The Wesley Hospital, Brisbane, Australia, ⁴Centre for Clinical Research, The University of Queensland, Brisbane, Australia, ⁵Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Australia, ⁶QIMR Berghofer Medical Research Institute, Brisbane, Australia, ⁷School of Information Technology and Electrical Engineering, The University of Queensland, St Lucia, Australia, ⁸Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ⁹Health and Biosecurity, The Commonwealth Scientific and Industrial Research Organisation (CSIRO), Brisbane, Australia

Synopsis

Segmentation and volumetric analysis of the hypothalamus and fornix plays a critical role in improving the understanding of degenerative processes that might impact the function of these structures. We present Open-Source Hypothalamic-ForniX (OSHy-X) atlases and tool for multi-atlas fusion segmentation for 3T and 7T. The atlases are based on 20 manual segmentations, which we demonstrate have high interrater agreement. The versatility of the OSHy-X tool allows segmentation and volumetric analysis for different field strengths and contrasts. We also demonstrate that OSHy-X segmentation has higher Dice overlaps (3T and 7T inputs: p<0005, p<0.005) than a deep-learning segmentation method for the hypothalamus.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.