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Abstract #3821

In Vivo T2* Mapping of Intracranial Atherosclerotic Plaque Distinguishes Symptom-Producing Plaques: a 7T MRI study

Ziming Xu1, Xiaoyan Bai2, Yajie Wang1, Zhiye Li2, Jiaqi Dou1, Binbin Sui3, and Huijun Chen1
1Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, 2Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, Beijing, China, 3Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China


In vivo quantitative mapping of intracranial atherosclerotic plaque is very important for plaque characterization. Previous intracranial plaque quantitative studies were usually carried out ex vivo, while studies of in vivo intracranial plaque mapping have rarely been reported. In this study, the in vivo feasibility of quantitative T2* mapping of intracranial plaque at 7T MRI had firstly been demonstrated. Symptomatic patients showed significantly lower intraplaque T2* values than asymptomatic patients (26.33 ± 7.16 vs. 33.47 ± 8.68 ms, p = 0.048). This quantitative and noninvasive assessment may serve as one potential tool to characterize and evaluate intracranial atherosclerotic plaques.

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