In vivo quantitative mapping of intracranial atherosclerotic plaque is very important for plaque characterization. Previous intracranial plaque quantitative studies were usually carried out ex vivo, while studies of in vivo intracranial plaque mapping have rarely been reported. In this study, the in vivo feasibility of quantitative T2* mapping of intracranial plaque at 7T MRI had firstly been demonstrated. Symptomatic patients showed significantly lower intraplaque T2* values than asymptomatic patients (26.33 ± 7.16 vs. 33.47 ± 8.68 ms, p = 0.048). This quantitative and noninvasive assessment may serve as one potential tool to characterize and evaluate intracranial atherosclerotic plaques.
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