Abstract #3827

Pulmonary Compliance Imaging Using Hyperpolarized Gas MRI

Ming Zhang¹, Haidong Li¹, Hongchuang Li¹, Xiuchao Zhao¹, Xiaoling Liu¹, Yeqing Han¹, Xianping Sun¹, Xin Lou², Chaohui Ye¹, and Xin Zhou¹

¹Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences- Wuhan National Laboratory for Optoelectronics, Wuhan, China, ²Department of Radiology, Chinese PLA General Hospital, Beijing, China

Synopsis

Pulmonary compliance is generally measured using ventilator and esophageal balloon in clinical practice, and only global compliance could be obtained. In this study, we proposed a method for imaging pulmonary compliance using hyperpolarized (HP) ¹²⁹Xe MRI. Lung compliance derived by HP ¹²⁹Xe MRI could be used for quantifying the injuries caused by fibrosis in rats.

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