Abstract #3829
The location reliability of the functional connectivity of deep emotion-related regions towards functional connectivity guided rTMS therapy
Na Zhao1,2,3,4,5, Juan Yue1,2,3, Zi-Jian Feng1,2,3, Yang Qiao 1,2,3,5,6, Li-Xia Yuan1,2,3, Jue Wang7, Yong Zhang8, Yu-Tao Xiang 4,5,9, and Yu-Feng Zang 1,2,3
1Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China, Hangzhou, China, 2Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China, Hangzhou, China, 3Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China, Hangzhou, China, 4Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China, Taipa, Macau, 5Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China, Taipa, Macau, 6Faculty of Health Sciences, University of Macau, Macao SAR, China, Taipa, Macau, 7Institute of sports medicine and health, Chengdu Sport University, Chengdu, China, Chengdu, China, 8MR Research, GE Healthcare, Shanghai, China, Shanghai, China, 9Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, China, Taipa, Macau
Synopsis
The current study systematically investigated multiple factors that affect the reliability of the FC location and strength of the DLPFC with a few emotional related deep regions. The group-level voxel-wise FC strength reliability was low to moderate, indicating its little significance for guiding individualized rTMS treatment. In terms of the FC location reliability, the intra-individual distances of the center of gravity (COG) were 3.8-7.3 mm across different conditions, which suggest that the COG of the seed-based FC might be potential stimulation target for individualized precise rTMS treatment of affective brain disorders.
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