Quasi-steady-state reconstruction provides fast equilibrium APT imaging of brain tumor patients at 3T
Yin Wu1, Zhou Liu1,2, Qian Yang2, Liyan Zou2, Fan Zhang2, Long Qian3, Xin Liu1, Hairong Zheng1, Dehong Luo2, and Phillip Zhe Sun4
1Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, 3GE Healthcare, Beijing, China, 4Emory University School of Medicine, Atlanta, GA, United States
APT MRI scans are often performed under non-equilibrium conditions, confounding imaging quantification and tissue characterization. This study proposed a quasi-steady-state (QUASS) algorithm for fast and accurate tumor APT imaging. Seven healthy volunteers and nineteen tumor patients were scanned at 3T, with two representative RF saturation times (Ts) and relaxation delays (Td). The routine APT measures significantly varied with Ts and Td (P<.001) and were significantly smaller than the corresponding QUASS indices (P<.001). In contrast, QUASS reconstruction results showed little dependence on scan protocols (P>.05). The QUASS algorithm enables robust APT imaging, promising to expedite and standardize clinical APT tumor MRI.
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