Abstract #3878

Probing evidence of brain macrostructural disruptions in coronary artery disease: A diffusion MRI tractometry study

Stefan E. Poirier^1,2, Neville Suskin³, Keith S. St. Lawrence^1,2, Christopher McIntyre^1,2,4, Jonathan D. Thiessen^1,2, J. Kevin Shoemaker⁵, and Udunna C. Anazodo^1,2

¹Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Cardiology, Western University, London, ON, Canada, ⁴Lilibeth Caberto Kidney Clinical Research Unit, London Health Sciences Centre, London, ON, Canada, ⁵School of Kinesiology, Western University, London, ON, Canada

Synopsis

White matter (WM) breakdown is linked to cognitive impairment in coronary artery disease (CAD). We used diffusion MRI tractometry to assess the effects of cardiac disease, brain aging, and cardiac rehabilitation (CR) on regional WM macrostructure in brains of CAD patients. WM disruptions were found in CAD patients at baseline (pre-CR) compared to controls and in old controls compared to young controls. WM improvements, especially in regions linked to cognition, were observed in CAD patients following CR. Both cardiac disease and brain aging may contribute to WM dysfunction in CAD, and these WM disruptions may be favourably modified by CR.

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