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Abstract #3882

Can Proximal Nerve Morphometrics Predict Disease Severity in Polyneuropathies?

Yongsheng Chen1, Alexandar Bezanovski1, Sadaf Saba1, Vince Marceau1, Yang Xuan2, Mariam Tariq1, Xue Yang1, and Jun Li1
1Neurology, Wayne State University School of Medicine, Detroit, MI, United States, 2Radiology, Wayne State University School of Medicine, Detroit, MI, United States

Synopsis

Human sciatic nerve morphometrics were measured for nerve volume, fascicle volume, and fascicle density using a 3D gradient echo sequence with an in-plane resolution of 0.15 x 0.15 mm2. Metrics from healthy controls showed a moderate correlation of nerve and fascicle volumes with body mass index but not with age. There was a strong correlation between nerve volume and the clinical score of disease severity in patients with hereditary neuropathy with liability to pressure palsies.

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