Abstract #3884

Quantitative susceptibility mapping of early myelination in the posterior limb of internal capsule in neonates

Brian Ma¹, Lara Bartels^1,2, Christian Kames^1,2, Yuting Zhang³, Alexander Weber^1,4, and Alexander Rauscher^1,2,4,5

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ³Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, China, ⁴Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁵Department of Radiology, University of British Columbia, Vancouver, BC, Canada

Synopsis

We performed quantitative susceptibility mapping (QSM) of the posterior limb of internal capsule (PLIC) in human neonates. As the PLIC is one of the earliest structures to myelinate, it is clearly visible as a hypointense structure on QSM. This work investigates the potential as a marker for brain health in neonates. There were no significant differences in magnetic susceptibility of the PLIC between healthy controls, injured preterm, and injured term neonates.

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