Abstract #3900

Unbiasing orientationally-averaged diffusion MRI signal

Tomasz Pieciak¹, Maryam Afzali^2,3, Antonio Tristán-Vega¹, and Santiago Aja-Fernández¹

¹Laboratorio de Procesado de Imagen (LPI), Universidad de Valladolid, Valladolid, Spain, ²Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, ³Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom

Synopsis

The orientationally-averaging or the so-called power-averaging is a common approach to reduce the impact of macroscopic anisotropy in diffusion MRI (dMRI). This paper analytically derives two new closed-form unbiased orientationally-averaging diffusion MRI signal estimators and shows that the noise-related bias could be significantly suppressed with these new findings. The new formulas might be applied to retrospectively orientationally-averaged dMRI signals with minimal computational effort.

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