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Abstract #3902

PET attenuation correction in lung with ZTE based pseudo-CT generation

Chang Sun1, Roido Manavaki1, Jason Tarkin2, Christopher Wall2, James HF Rudd2, Fiona J Gilbert1, and Martin J Graves1
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom


Attenuation correction methods in body PET/MRI do not consider lung density variations within and between participants, which can significantly affect PET image quantification in thoracic areas. We developed a hybrid ZTE-based/Dixon method for MR-based attenuation correction, which resulted in a pseudo-CT image (Dixon/pCT) and used for attenuation correction in the lung. PET images corrected with the Dixon/pCT attenuation map were compared to images produced with manufacturer’s Dixon attenuation map and a hybrid Dixon/CT image. Overall, the Dixon/pCT method reduced the absolute SUV error in the lung by 3%, when compared to the Dixon attenuation correction.

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