Abstract #3911

Oxygen Transport Modelling for Mapping Brain Oxygen Extraction Fraction with Single Gas Calibrated fMRI

Antonio Maria Chiarelli¹, Michael Germuska², Hannah Chandler², Rachael Stickland³, Eleonora Patitucci², Emma Biondetti¹, Daniele Mascali¹, Neeraj Saxena², Sharmila Khot², Jessica Steventon², Catherine Foster⁴, Ana E Rodríguez-Soto⁵, ‪Erin Englund⁶, Kevin Murphy², Valentina Tomassini^1,2,7, Felix W Wehrli⁸, and Richard Wise^1,2

¹Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti Pescara, Chieti Scalo, Italy, ²Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff, United Kingdom, ³Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ⁴Cardiff University, Cardiff, United Kingdom, ⁵University of California, San Diego, La Jolla, CA, United States, ⁶University of Colorado, Colorado, CO, United States, ⁷MS Centre, Dept of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy, ⁸Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Dual-calibrated functional MRI (dc-fMRI) can map brain oxygen extraction fraction (OEF) by measuring BOLD-ASL signal changes during arterial O₂ and CO₂ modulations. Two modulations are required to decouple OEF and the deoxyhemoglobin-sensitive blood volume. Here, we propose a single gas calibrated approach that integrates a model of oxygen transport that links blood volume and CBF to OEF. Simulations demonstrated the method’s viability. In-vivo application with hypercapnia provided estimates of grey matter OEF in agreement with dc-fMRI and with whole-brain OEF derived from signal phase measures in the superior sagittal sinus. The simplified calibrated fMRI method holds promise for clinical application.

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