Abstract #3911
Oxygen Transport Modelling for Mapping Brain Oxygen Extraction Fraction with Single Gas Calibrated fMRI
Antonio Maria Chiarelli1, Michael Germuska2, Hannah Chandler2, Rachael Stickland3, Eleonora Patitucci2, Emma Biondetti1, Daniele Mascali1, Neeraj Saxena2, Sharmila Khot2, Jessica Steventon2, Catherine Foster4, Ana E Rodríguez-Soto5, Erin Englund6, Kevin Murphy2, Valentina Tomassini1,2,7, Felix W Wehrli8, and Richard Wise1,2
1Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti Pescara, Chieti Scalo, Italy, 2Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff, United Kingdom, 3Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 4Cardiff University, Cardiff, United Kingdom, 5University of California, San Diego, La Jolla, CA, United States, 6University of Colorado, Colorado, CO, United States, 7MS Centre, Dept of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy, 8Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States
Synopsis
Dual-calibrated functional MRI (dc-fMRI) can map brain oxygen extraction fraction (OEF) by measuring BOLD-ASL signal changes during arterial O2 and CO2 modulations. Two modulations are required to decouple OEF and the deoxyhemoglobin-sensitive blood volume. Here, we propose a single gas calibrated approach that integrates a model of oxygen transport that links blood volume and CBF to OEF. Simulations demonstrated the method’s viability. In-vivo application with hypercapnia provided estimates of grey matter OEF in agreement with dc-fMRI and with whole-brain OEF derived from signal phase measures in the superior sagittal sinus. The simplified calibrated fMRI method holds promise for clinical application.
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