Using a simple linear model, we predicted myelin-specific PSR maps from clinically available images. We trained this linear model on various combinations of routine images, including gray-matter standardized T1- and T2-weighted images and diffusion maps. The model reasonably predicted PSR values from structural images alone, although model performance was improved by the addition of diffusion parameters. In the future, this model may enable researchers and clinicians to assess myelin status without the need for specialized myelin imaging sequences. In addition, myelin maps could be obtained retrospectively in large imaging databases without myelin specific methods.
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