Abstract #4000

Assessment of Placental Perfusion in Normal and Hypertensive Pregnancies using pCASL at 3T: Preliminary Findings

Yiming Wang¹, Christina L. Herrera², David M. Owen², Quyen N. Do¹, Yin Xi^1,3, Matthew A. Lewis¹, Baowei Fei^1,4,5, Catherine Y. Spong², Diane M. Twickler^1,2, and Ananth J. Madhuranthakam^1,4

¹Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX, United States, ³Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States

Synopsis

Measuring placental perfusion can provide important information about its function. Arterial Spin Labeled (ASL) MRI is a non-contrast perfusion imaging method particularly suitable in pregnancy as it does not require an exogenous contrast. We performed a preliminary assessment of placental perfusion in pregnant subjects, both normal and with CHTN, at 16-20 week and 24-28 week gestational ages. Perfusion reduction was observed in all 5 normal subjects and in 75% (12 of 16) of the subjects with CHTN. This could provide important information about perfusion changes during pregnancy and can serve as a precursor for a larger-scale longitudinal study in CHTN.

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