Abstract #4000
Assessment of Placental Perfusion in Normal and Hypertensive Pregnancies using pCASL at 3T: Preliminary Findings
Yiming Wang1, Christina L. Herrera2, David M. Owen2, Quyen N. Do1, Yin Xi1,3, Matthew A. Lewis1, Baowei Fei1,4,5, Catherine Y. Spong2, Diane M. Twickler1,2, and Ananth J. Madhuranthakam1,4
1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States, 4Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 5Department of Bioengineering, University of Texas at Dallas, Richardson, TX, United States
Synopsis
Measuring placental perfusion can provide important information about its function. Arterial Spin Labeled (ASL) MRI is a non-contrast perfusion imaging method particularly suitable in pregnancy as it does not require an exogenous contrast. We performed a preliminary assessment of placental perfusion in pregnant subjects, both normal and with CHTN, at 16-20 week and 24-28 week gestational ages. Perfusion reduction was observed in all 5 normal subjects and in 75% (12 of 16) of the subjects with CHTN. This could provide important information about perfusion changes during pregnancy and can serve as a precursor for a larger-scale longitudinal study in CHTN.
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