Abstract #4002
Bilateral asymmetry of early parenchymal kinetics predicts response of breast cancer to neoadjuvant therapy
Zhen Ren1, Federico D. Pineda1, Frederick M. Howard2, Elle Hill1, Teodora Szasz3, Rabia Safi1, Milica Medved1, Rita Nanda2, Thomas E. Yankeelov4,5,6,7,8,9, Hiroyuki Abe1, and Gregory S. Karczmar1
1Radiology, The University of Chicago, Chicago, IL, United States, 2Medicine, The University of Chicago, Chicago, IL, United States, 3Research Computing Center, The University of Chicago, Chicago, IL, United States, 4Biomedical Engineering, The University of Texas at Austin,, Austin, TX, United States, 5Diagnostic Medicine, The University of Texas at Austin, Austin, TX, United States, 6Oncology, The University of Texas at Austin, Austin, TX, United States, 7Institute for Computational and Engineering Sciences, The University of Texas at Austin, Austin, TX, United States, 8Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX, United States, 9Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States
Synopsis
We retrospectively reviewed data from 23 patients who received neoadjuvant therapy (NAT) and were scanned with a protocol that included ultrafast DCE-MRI (temporal resolution = 3-7 seconds) for the first minute after contrast injection prior to NAT. We measured parenchymal kinetics from ipsi- and contra-lateral normal parenchyma separately, so that new parameters related to bilateral parenchymal enhancement asymmetry could be calculated. The results showed that patients with similar pre-NAT parenchymal enhancement kinetics in ipsi- and contralateral normal parenchyma were more likely to achieve pCR post NAT ($$$p < 0.02$$$).
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