Abstract #4002

Bilateral asymmetry of early parenchymal kinetics predicts response of breast cancer to neoadjuvant therapy

Zhen Ren¹, Federico D. Pineda¹, Frederick M. Howard², Elle Hill¹, Teodora Szasz³, Rabia Safi¹, Milica Medved¹, Rita Nanda², Thomas E. Yankeelov^4,5,6,7,8,9, Hiroyuki Abe¹, and Gregory S. Karczmar¹

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Medicine, The University of Chicago, Chicago, IL, United States, ³Research Computing Center, The University of Chicago, Chicago, IL, United States, ⁴Biomedical Engineering, The University of Texas at Austin,, Austin, TX, United States, ⁵Diagnostic Medicine, The University of Texas at Austin, Austin, TX, United States, ⁶Oncology, The University of Texas at Austin, Austin, TX, United States, ⁷Institute for Computational and Engineering Sciences, The University of Texas at Austin, Austin, TX, United States, ⁸Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX, United States, ⁹Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States

Synopsis

We retrospectively reviewed data from 23 patients who received neoadjuvant therapy (NAT) and were scanned with a protocol that included ultrafast DCE-MRI (temporal resolution = 3-7 seconds) for the first minute after contrast injection prior to NAT. We measured parenchymal kinetics from ipsi- and contra-lateral normal parenchyma separately, so that new parameters related to bilateral parenchymal enhancement asymmetry could be calculated. The results showed that patients with similar pre-NAT parenchymal enhancement kinetics in ipsi- and contralateral normal parenchyma were more likely to achieve pCR post NAT ($$$p < 0.02$$$).

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