Prostate dynamic contrast-enhanced (DCE) MRI is often criticized for its weaknesses in terms of discriminating transition zone lesions and tumors in general. Using high-temporal resolution DCE MRI in patients who went on to prostatectomy, we evaluated time to peak (TTP), as well as the enhancement rate factor, and initial enhancement slope of a simple empirical mathematical model of early contrast uptake. Differences between tumors and surrounding healthy tissues were seen for the mean values of all three parameters. The AUCs were good (>0.8 in all cases except for TTP between tumor and transition zone) but case numbers limited.
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