Observations on Rapid Dynamic Contrast Enhanced MRI in Prostate Cancer
Armando Tartaro1,2, Roberto Renzetti3, Michele De Cristofaro Aulisa4, Federica Morrone5, Andrea De Nicola6,7, Ekaterina Bliakharskaia7, and Paul E Summers7
1Department of Clinical, Oral and Biotechnology Sciences, University "G. d'Annunzio" Chieti-Pescara, Chieti-Pescara, Italy, 2Magnetic Resonance Service, Ospedale di Popoli, AUSL, Pescara, Italy, 3UOC of Urology, Ospedale di Pescara, AUSL, Pescara, Italy, 4Faculty of Medicine, University "G. d'Annunzio“, Chieti-Pescara, Chieti-Pescara, Italy, 5Radiology Department, Centro Morrone, Caserta, Italy, 6Ospedale di Chieti, Chieti, Italy, 7QMRI Tech, Pescara, Italy
Prostate dynamic contrast-enhanced (DCE) MRI is often criticized for its weaknesses in terms of discriminating transition zone lesions and tumors in general. Using high-temporal resolution DCE MRI in patients who went on to prostatectomy, we evaluated time to peak (TTP), as well as the enhancement rate factor, and initial enhancement slope of a simple empirical mathematical model of early contrast uptake. Differences between tumors and surrounding healthy tissues were seen for the mean values of all three parameters. The AUCs were good (>0.8 in all cases except for TTP between tumor and transition zone) but case numbers limited.
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