Abstract #4012

Quantitative analysis of ultrafast DCE-MRI to distinguish benign and malignant breast lesions in a clinical setting

Anum S. Kazerouni¹, Yun An Chen¹, Callie Lind², Inyoung Youn³, Savannah C. Partridge¹, and Habib Rahbar¹

¹Radiology, University of Washington, Seattle, WA, United States, ²Bioengineering, University of Washington, Seattle, WA, United States, ³Radiology, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of

Synopsis

We investigate the ability of quantitative measures derived from ultrafast DCE-MRI to improve breast MRI specificity for lesion diagnosis in a clinical setting. Sixty-nine women with BI-RADS 3, 4, or 5 lesions identified on clinical breast MRI exam, with subsequent diagnostic biopsy, were retrospectively identified. Ultrafast DCE-MRI was used to calculate semi-quantitative (bolus arrival time, max slope) and quantitative (K^trans, v_p) features for each lesion visible on the ultrafast series. Malignant lesions showed significantly higher v_p compared to benign lesions. Combined with qualitative assessment of visibility on ultrafast DCE-MRI (“yes”/“no”), v_p showed an AUC=0.73 for lesion diagnosis.

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