In this study, we investigated whether prenatal alcohol exposure (PAE) disrupts the coupling strength between SC and static FC or dynamic FC using multimodal connectomes. Greater coupling strengths were identified in the PAE T1 and PAE T1-T3 groups within males, indicative of brain structural and functional changes in children with PAE. Distinct age effects on coupling strength were also revealed. Further, the reduction of assortative coefficients indicated that PAE could compromise the robustness of brain networks. These findings suggest that multimodal connectomes, especially integrating network dynamics, could be advantageous to revealing brain structural and functional changes.
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