Abstract #4026

Disrupted structural-functional coupling in children with prenatal alcohol exposure

Xiaoyun Liang^1,2, Chun-Hung Yeh^3,4, and Peter J. Anderson^1,5

¹Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, ²Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia, ³Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁴Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁵Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia

Synopsis

In this study, we investigated whether prenatal alcohol exposure (PAE) disrupts the coupling strength between SC and static FC or dynamic FC using multimodal connectomes. Greater coupling strengths were identified in the PAE T1 and PAE T1-T3 groups within males, indicative of brain structural and functional changes in children with PAE. Distinct age effects on coupling strength were also revealed. Further, the reduction of assortative coefficients indicated that PAE could compromise the robustness of brain networks. These findings suggest that multimodal connectomes, especially integrating network dynamics, could be advantageous to revealing brain structural and functional changes.

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