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Abstract #4058

Enhanced detection of paramagnetic fluorine-19 MRI agents using compressed sensing zero echo time sequence

Jiawen Chen1, Piya Pal1, and Eric Ahrens2
1Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, United States, 2Department of Radiology, University of California San Diego, La Jolla, CA, United States


To accelerate the imaging speed and improve the signal-to-noise ratio of three-dimensional, whole body 19F MRI, we describe an ultrafast compressed sensing data acquisition scheme adapted for a zero echo time (ZTE) pulse sequence, with data reconstruction via a sparsity-promoting algorithm using a nonuniform fast Fourier transform (NUFFT) sensing operator. These methods are well suited for MRI of labeled cells using 19F tracer agents, particularly paramagnetic metallo-perfluorocarbon nanoemulsions. In phantom data and an in vivo immunotherapy mouse model, we show the feasibility of boosting MRI detection sensitivity by greater than an order of magnitude without increasing total scan time.

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