To accelerate the imaging speed and improve the signal-to-noise ratio of three-dimensional, whole body 19F MRI, we describe an ultrafast compressed sensing data acquisition scheme adapted for a zero echo time (ZTE) pulse sequence, with data reconstruction via a sparsity-promoting algorithm using a nonuniform fast Fourier transform (NUFFT) sensing operator. These methods are well suited for MRI of labeled cells using 19F tracer agents, particularly paramagnetic metallo-perfluorocarbon nanoemulsions. In phantom data and an in vivo immunotherapy mouse model, we show the feasibility of boosting MRI detection sensitivity by greater than an order of magnitude without increasing total scan time.
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