Abstract #4060

In vivo phase-incrementing SEE-HSelMQC method to resolve tumor biomarker images by synchronizing RF phase increments and phase-encoding steps

Qiuhong He^1,2, Hong Yuan^2,3, and Yen-Yu Ian Shih^1,2,4

¹Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

We have developed the phase-incrementing MRSI (pi-MRSI) method to resolve overlapping biomarker images in the presence of a frequency encoding gradient during acquisition time. We report here the pi-SEE-HSelMQC experiments on a pre-clinical Bruker 9.4T spectrometer. The choline-selective and lactate CH-selective RF pulses in the pulse sequence were phase incremented by 10° in opposite signs in synchronization with the phase-encoding steps. In vivo two-dimensional pi-SEE-HSelMQC imaging of lactate and choline acquired from the PC3 human prostate cancer xenograft in a nude mouse showed opposite image offsets, shifted away from spurious signals. The pi-SEE-HSelMQC method completely suppresses lipid and water.

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