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Abstract #4069

Subject-specific Analysis for Diffusion and Kurtosis Changes in mild Traumatic Brain Injury (mTBI) Patients

Chitresh Bhushan1, Nastaren Abad1, Radhika Madhavan2, Luca Marinelli1, H. Doug Morris3, Maureen Hood3,4, J Kevin DeMarco3, Robert Y Shih3,4, Ante Zhu1, Gail Kohls3, Eric Fiveland1, Kimbra Kenney3,4, Vincent B Ho3,4, and Thomas K Foo1,4
1GE Research, Niskayuna, NY, United States, 2GE Healthcare, Niskayuna, NY, United States, 3Walter Reed National Military Medical Center, Bethesda, MD, United States, 4Uniformed Services University of the Health Sciences, Bethesda, MD, United States


Advanced neuroimaging capabilities enabled by the MAGNUS (ultra-high performance head gradient) system was leveraged in this study to assess subject-specific microstructural changes with acute and chronic mild traumatic brain injury. MAGNUS allows for a four-fold increase in maximum gradient-amplitude compared to current clinical whole-body scanners and enables identification of new imaging biomarkers for improved detection of microstructural changes in the brain. We present an outlier analysis approach that allows study of microstructure differences in individual subjects rather than solely on a group basis. Preliminary results demonstrate identification of several white-matter regions in patient groups that differ from healthy controls.

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