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Abstract #4075

The dependence of the resting-state macrovascular fMRI signal power on vascular volume and orientation: A simulation study

Xiaole Zhong1,2 and J. Jean Chen1,2
1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada


The resting-state fMRI (rs-fMRI) signal fluctuation amplitude is widely used as the resting-state fMRI marker, but it could be biased by the contribution of macrovessels. We demonstrate the dependence of the macrovascular contribution on blood oxygenation, vascular occupancy and orientation. This work paves the way for more appropriate interpretation of rs-fMRI signal amplitude given different vascular morphology across brain regions and populations.

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