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Abstract #4079

The frequency dependence of the resting-state fMRI signal on macrovascular volume and orientation

Xiaole Zhong1,2 and J. Jean Chen1,2
1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada


Frequency analysis of the BOLD fMRI signal is increasingly finding application, including in evaluating denoising procedures and biological brain changes. In resting-state fMRI (rs-fMRI), the signal frequency can be biased by contributions from large vessels, but this phenomenon is uninvestigated. In this work, we show that the rs-fMRI frequency content varies with both vascular volume fraction and orientation. Moreover, arteries and veins contribute differently to these variations.

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