Frequency analysis of the BOLD fMRI signal is increasingly finding application, including in evaluating denoising procedures and biological brain changes. In resting-state fMRI (rs-fMRI), the signal frequency can be biased by contributions from large vessels, but this phenomenon is uninvestigated. In this work, we show that the rs-fMRI frequency content varies with both vascular volume fraction and orientation. Moreover, arteries and veins contribute differently to these variations.
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