Abstract #4135

Introduction of the Right Ventricular-Arterial Coupling Index in CMR Reflecting Lung Histological Changes in Experimental PAH

Ali Nahardani^1,2, Katja Grün³, Martin Krämer², Karl-Heinz Herrmann², Andrea Schrepper⁴, Sara Moradi¹, Jürgen R. Reichenbach², Marcus Franz³, and Verena Hoerr^1,2,5

¹Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany, ²Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany, ³Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, Jena, Germany, ⁴Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany, ⁵Translational Research Imaging Center (TRIC), Clinic for Radiology, University Hospital Muenster, Muenster, Germany

Synopsis

The current preclinical study aims to investigate the associativity between the ventricular-arterial coupling index (VAC) derived by CMR and microscopic vascular changes in pulmonary arterial hypertension (PAH). To this end, three stages of disease were incorporated in the study: healthy, moderate, and severe. All animals underwent CMR and echocardiography. The corresponding lung tissue was also assessed histologically. The right VAC could predict the presence of histopathological changes with r=-0.95 and had a strong correlation with tricuspid annular plane systolic excursion (r=0.90).

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