Introduction of the Right Ventricular-Arterial Coupling Index in CMR Reflecting Lung Histological Changes in Experimental PAH
Ali Nahardani1,2, Katja Grün3, Martin Krämer2, Karl-Heinz Herrmann2, Andrea Schrepper4, Sara Moradi1, Jürgen R. Reichenbach2, Marcus Franz3, and Verena Hoerr1,2,5
1Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany, 2Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany, 3Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, Jena, Germany, 4Department of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany, 5Translational Research Imaging Center (TRIC), Clinic for Radiology, University Hospital Muenster, Muenster, Germany
The current preclinical study aims to investigate the associativity between the ventricular-arterial coupling index (VAC) derived by CMR and microscopic vascular changes in pulmonary arterial hypertension (PAH). To this end, three stages of disease were incorporated in the study: healthy, moderate, and severe. All animals underwent CMR and echocardiography. The corresponding lung tissue was also assessed histologically. The right VAC could predict the presence of histopathological changes with r=-0.95 and had a strong correlation with tricuspid annular plane systolic excursion (r=0.90).
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