Diffusion MRI could provide unique information non-invasively. However, it is still a technical challenge due to the intrinsic non-rigid motion during the cardiac cycle, displacement of the myocardium due to respiratory motion, field inhomogeneity, and short T1 and T2 values. Parallel imaging and Zoom imaging based on 2D RF (iZoom) could both reduce the distortion dramatically, second order flow compensated diffusion could be used to decrease the impact of motion. We propose a solution that combines iZoom, SENSE and the 2nd flow compensated diffusion to generate a robust cardiac diffusion MRI, its robustness was validated by a preliminary study.
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