Fast High-Resolution 3D MRSI and T2 Mapping for Clinical Outcome Prediction of Ischemic Stroke Patients
Ziyu Meng1, Tianyao Wang2, Bin Bo1, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Xin Yu5, Zhi-Pei Liang3,4, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States
Characterization of the underlying pathophysiological changes associated with edema progression is essential for treatment guidance in ischemic stroke. 1H-MRSI and quantitative T2 mapping can acquire image markers related to the physiological states of brain tissues. This study investigated the neurometabolite changes in relation to the development of vasogenic edema in ischemic stroke patients, using fast high-resolution 3D MRSI and T2 mapping techniques. Our results showed that neurometabolite concentrations were strongly correlated with T2 values within ischemic lesion of stroke patients and integrated T2 and neurometabolite biomarkers improved the prediction accuracy of stroke patients' clinical outcome.
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