Characterization of the underlying pathophysiological changes associated with edema progression is essential for treatment guidance in ischemic stroke. 1H-MRSI and quantitative T2 mapping can acquire image markers related to the physiological states of brain tissues. This study investigated the neurometabolite changes in relation to the development of vasogenic edema in ischemic stroke patients, using fast high-resolution 3D MRSI and T2 mapping techniques. Our results showed that neurometabolite concentrations were strongly correlated with T2 values within ischemic lesion of stroke patients and integrated T2 and neurometabolite biomarkers improved the prediction accuracy of stroke patients' clinical outcome.
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