Noninvasive perfusion mapping is important to determine perfusion changes due to molecular and neuropathological modifications as well as pharmaceutical interventions. Here, we adopted a dynamic BOLD-MRI method for quantifying whole brain perfusion, such as cerebral blood volume (CBV) and cerebral blood flow (CBF) without the use of exogenous contrast agents in mice. High-resolution perfusion maps allow us to determine regional perfusion values and cortical depth-dependency. The proposed technique is non-invasive and repeatable with every <1 min temporal resolution and can combine with evoked fMRI studies for determining a neural activity-induced quantitative change of perfusion parameters.
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