Meeting Banner
Abstract #4145

Rapid high-resolution mapping of cerebral blood flow and volume by dynamic BOLD MRI with transient hypoxia in mice

Dongkyu Lee1, Thi Thuy Le1, Geun Ho Im1, and Seong-Gi Kim1
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of


Noninvasive perfusion mapping is important to determine perfusion changes due to molecular and neuropathological modifications as well as pharmaceutical interventions. Here, we adopted a dynamic BOLD-MRI method for quantifying whole brain perfusion, such as cerebral blood volume (CBV) and cerebral blood flow (CBF) without the use of exogenous contrast agents in mice. High-resolution perfusion maps allow us to determine regional perfusion values and cortical depth-dependency. The proposed technique is non-invasive and repeatable with every <1 min temporal resolution and can combine with evoked fMRI studies for determining a neural activity-induced quantitative change of perfusion parameters.

This abstract and the presentation materials are available to members only; a login is required.

Join Here