Abstract #4167

Early MR radiomic biomarkers for re-hemorrhage after Gamma Knife Radiosurgery in Cavernous Malformation

Pei-Hsuan Kuo¹, Cheng-Chia Lee^2,3,4, Huai-Che Yang^2,3, Hsiu-Mei Wu^3,5, and Chia-Feng Lu¹

¹Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²Department of Neurosurgery, Neurological Institute, Taipei Veteran General Hospital, Taipei, Taiwan, ³School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ⁴Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ⁵Department of Radiology, Taipei Veteran General Hospital, Taipei, Taiwan

Synopsis

Cavernous malformation (CM) is one of the common cerebral vascular diseases. Hemorrhage is a common and dangerous symptom of CMs, and re-hemorrhage may still occur in 30% of patients after the treatment of Gamma Knife radiosurgery (GKRS). Till now, the prediction of occurrences of future re-hemorrhage in CMs are still less explored. In this study, we used statistical analyses to observe longitudinal changes in MRI radiomic features before re-hemorrhage after GKRS. We aimed to identify the reliable image biomarkers using the quantitative and non-invasive MRI technique as early predictors to guide the clinical management for CM patients.

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