Early MR radiomic biomarkers for re-hemorrhage after Gamma Knife Radiosurgery in Cavernous Malformation
Pei-Hsuan Kuo1, Cheng-Chia Lee2,3,4, Huai-Che Yang2,3, Hsiu-Mei Wu3,5, and Chia-Feng Lu1
1Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Department of Neurosurgery, Neurological Institute, Taipei Veteran General Hospital, Taipei, Taiwan, 3School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, 4Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, 5Department of Radiology, Taipei Veteran General Hospital, Taipei, Taiwan
Cavernous malformation (CM) is one of the common cerebral vascular diseases. Hemorrhage is a common and dangerous symptom of CMs, and re-hemorrhage may still occur in 30% of patients after the treatment of Gamma Knife radiosurgery (GKRS). Till now, the prediction of occurrences of future re-hemorrhage in CMs are still less explored. In this study, we used statistical analyses to observe longitudinal changes in MRI radiomic features before re-hemorrhage after GKRS. We aimed to identify the reliable image biomarkers using the quantitative and non-invasive MRI technique as early predictors to guide the clinical management for CM patients.
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