Previous DTI studies mainly detected partial ROIs or mean diffusion profiles of corticospinal tract (CST), few revealed changes along CST trajectory. We used Automated Fiber Quantification (AFQ) derived from DTI to investigate whether diffusion parameters changes were localized to its specific regions or spread throughout. The results showed AFQ traced out a clearer picture of the damaged CST along its trajectory in patients with hemiplegia after stroke. Furthermore, the severity of several damaged CST segments was correlated with motor scores, possibly providing more accurate and reliable "target" regions for assessing clinical prognosis and the efficacy of motor rehabilitation.
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