Meeting Banner
Abstract #4174

Characterization of Corticospinal Tract Injury along Fibers by Automated Fiber Quantification in Stroke

Fan Liu1, Yu Wei1, Qiurong Yu1, Hewei Wang2, Dazhi Yin3, Guojun Xu1, Miao Guo1, Ling Liu1, Qianwen Li1, and Mingxia Fan1
1Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China, 2Department of rehabilitation, Huashan Hospital, Fudan University, Shanghai, China, 3School of Psychology and Cognitive Science, East China Normal University, Shanghai, China


Previous DTI studies mainly detected partial ROIs or mean diffusion profiles of corticospinal tract (CST), few revealed changes along CST trajectory. We used Automated Fiber Quantification (AFQ) derived from DTI to investigate whether diffusion parameters changes were localized to its specific regions or spread throughout. The results showed AFQ traced out a clearer picture of the damaged CST along its trajectory in patients with hemiplegia after stroke. Furthermore, the severity of several damaged CST segments was correlated with motor scores, possibly providing more accurate and reliable "target" regions for assessing clinical prognosis and the efficacy of motor rehabilitation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here